A day after sister Serena endured a heart-breaking Wimbledon exit after suffering an injury in the first round, Venus Williams also bowed out of the singles on Wednesday.
Venus, aged 41 and playing in her 90th Grand Slam tournament, pushed Tunisian 21st seed Ons Jabeur hard in the opening set but eventually succumbed to a 7-5 6-0 defeat.
It is the first time at least one of the American sisters has failed to reach the third round at Wimbledon since Serena made her debut at the tournament in 1998.
Seven-time Wimbledon champion Serena was forced to quit against Aliaksandra Sasnovich on Centre Court after slipping in the first set and injuring her leg, ending another attempt to claim a record-equalling 24th Grand Slam title.
Venus said it had been hard to watch her younger sibling's tearful exit the previous day.
"Absolutely couldn't watch. It was too much. I just couldn't watch it. I know exactly what that feels like when all your faculties are taken away, things you work hard for and earn, and suddenly life happens," she said.
Asked how Serena was, she said: "I think she's doing the best you can when you get hurt. It's awful. It sucks."
Venus still has interest in the tournament as she will be playing the mixed doubles with Nick Kyrgios.
Carrying a red floral wreath bearing his shirt number, Diogo Jota's Liverpool teammates joined relatives and residents in a small Portuguese town on Saturday for the funeral of the football star, who died with his brother in a car crash on Thursday.
An 83rd-minute Weverton own goal from a deflected Malo Gusto cross gave Chelsea a nervy 2-1 win over a spirited Palmeiras side in the Club World Cup quarter-finals on Friday.
Women's top seed Aryna Sabalenka fought off inspired home favourite Emma Raducanu in a cauldron-like Centre Court atmosphere to keep her Wimbledon quest on track but it was the end of the road for two other Grand Slam champions on Friday.
India finished day three of the second test on 64-1 to lead England by 244 runs after they dismissed the hosts for 407 in the first innings at Edgbaston on Friday despite Jamie Smith's commanding and unbeaten knock of 184.
There were to be no Fourth of July celebrations for American Madison Keys as she joined the exodus of seeds from Wimbledon with a 6-3 6-3 defeat by 104th-ranked German Laura Siegemund in the third round on Friday.