German prosecutors believe British girl Madeleine McCann, who disappeared in Portugal in 2007, is dead.
"We assume that the girl is dead," Braunschweig state prosecutor Hans Christian Wolters said on Thursday.
It comes after an imprisoned German child abuser has been identified as a murder suspect.
While his name has not been revealed, the Metropolitan Police said he is 43-years-old and had been in and around the Praia da Luz resort in Algarve at the time of her disappearance.
"All we have ever wanted is to find her, uncover the truth and bring those responsible to justice," her parents, Kate and Gerry, said in a statement issued before the German prosecutor spoke.
"We will never give up hope of finding Madeleine alive but whatever the outcome may be, we need to know as we need to find peace."
McCann's disappearance from her room on May 3 during a family vacation in Algarve while her parents were dining with friends nearby had sparked an international search.
The death toll from Sunday's collision between a derailing high-speed train and a second oncoming train in southern Spain has risen to 39, with 152 people injured, state broadcaster RTVE reported on Monday, citing police sources.
Pakistani firefighters began pulling bodies from the smouldering remains of a sprawling Karachi shopping mall on Monday where more than 60 people were still missing after a massive fire that killed at least 21.
Wildfires in Chile have left at least 19 people dead, authorities said on Monday, as the government carried out mass evacuations and fought nearly two dozen blazes exacerbated by intense heat and high winds.
British Prime Minister Keir Starmer called on Monday for calm discussion to avert a possible trade war with the United States over Greenland, appealing to President Donald Trump to respect alliances such as NATO rather than undermine them.
A man died and several houses collapsed after an earthquake of magnitude 6 struck northwestern Kashmir in Pakistan on Monday, an official and the European Mediterranean Seismological Centre (EMSC) said.