Serena Williams has missed out on winning a record-equalling 24th Grand Slam singles title on home soil this year.
She was beaten 1-6, 6-3, 6-3 in the semi-finals of the U.S. Open by Victoria Azarenka.
The unseeded Belarusian will play Japan's Naomi Osaka in the final on Saturday.
It will be Azarenka's third final at Flushing Meadows, having lost the previous two to Williams in 2012 and 2013.
Fourth seed Osaka had earlier beaten 28th seed Jennifer Brady 7-6, 3-6, 6-3 in the other semi-final.
Iraq qualify for World Cup with win over Bolivia
Iraq has grabbed the last available place at the World Cup by beating Bolivia 2-1 in their inter-confederation playoff on Tuesday, sealing their return to the finals after a 40-year absence.
DR Congo score extra-time winner to qualify for World Cup
The Democratic Republic of Congo has qualified for the World Cup for the first time since 1974 after Axel Tuanzebe netted an extra-time winner to see off Jamaica 1-0 in their inter-confederation playoff on Tuesday.
Brazil score twice late on to beat Croatia 3-1 in World Cup tune-up
Brazil has beaten Croatia 3-1 in a World Cup warm-up in Orlando on Tuesday, with Igor Thiago converting a late penalty and Gabriel Martinelli adding a stoppage-time goal to seal the win.
Italy, Denmark miss out on World Cup after shootout defeats
Italy failed to qualify for a third consecutive World Cup after losing in a penalty shoutout against Bosnia-Herzegovina in their playoff final, while Denmark suffered the same fate against the Czech Republic.
Tiger Woods pleads not guilty, will seek treatment
Tiger Woods, on Tesday, released his first public statement since his rollover crash on Friday, announcing he would step away from golf to seek treatment in hopes of "lasting recovery".
