According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Sinner eases into French Open second round
World number one Jannik Sinner started his campaign for a maiden French Open title in merciless fashion, beating Frenchman Clement Tabur 6-1 6-3 6-4 to reach the second round on Tuesday.
Bengaluru secure IPL final berth after win over Gujarat
Royal Challengers Bengaluru stormed into the Indian Premier League (IPL) final with a commanding 92-run win over Gujarat Titans in qualifier one, powered by captain Rajat Patidar's unbeaten 93 that moved the defending champions closer to a second successive title.
Medvedev stunned by wildcard Walton in French Open first round
Daniil Medvedev could not avoid the French Open first‑round trapdoor as he fell 6-2 1-6 6-1 1-6 6-4 to Australian wildcard Adam Walton on Tuesday in a match marked by sharp swings in momentum on the Parisian clay.
Zee Entertainment in talks to stream FIFA World Cup in India
India's Zee Entertainment is in talks with FIFA to stream and broadcast the 2026 World Cup in the country, the company said in a statement on Tuesday.
Quick and effective: Sabalenka races into French Open second round
World number one Aryna Sabalenka blazed through her opening round at the French Open as she brushed aside Spain’s Jessica Bouzas Maneiro 6-4 6-2 on Tuesday.
