According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
UAE, Saudi Arabia set for Gulf Cup final showdown
The UAE face hosts Saudi Arabia in the final of the 27th Arabian Gulf Cup on Tuesday in Jeddah, with both sides aiming to end long waits for regional football's most prestigious title.
Djokovic wins China Open as de Minaur retires injured
Novak Djokovic won his seventh China Open title after Australia's Alex de Minaur retired with a groin injury during the final on Tuesday.
Alcaraz sinks Lehecka to retain Japan Open crown
Defending champion Carlos Alcaraz defeated unseeded Czech Jiri Lehecka 7-6(4) 6-4 in the Japan Open final on Tuesday to retain his title and continue his resurgence after a wrist injury.
McIlroy set for Dubai return at DP World Tour Championship in November
Seven-time Race to Dubai champion Rory McIlroy will tee it up at the DP World Tour Championship from November 12-15 at Jumeirah Golf Estates in Dubai, as he bids to draw level with Colin Montgomerie's record haul of eight Harry Vardon Trophies.
Kaur steps down as India women's team captain
World Cup-winning skipper Harmanpreet Kaur announced on Tuesday her decision to step down from her role as captain of the Indian women's team in all formats.
