According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Sri Lanka fight back through spinners but India 460-9
Sri Lanka struck back through spinners but Devdutt Padikkal's elegant 167 powered India to a commanding 460-9 in the rain-plagued opening test in Galle on Sunday.
Man arrested on suspicion of fraud after security operation disrupts European Championships
A man in his 30s was arrested and remains in custody on suspicion of fraud, West Midlands Police said on Sunday, after a security operation caused disruption at the European Athletics Championships in Birmingham the previous evening.
Bangladesh claim first test win in Australia as Green ton in vain
Bangladesh has chased down 57 runs to complete a landmark nine-wicket victory over Australia in the series-opener in Darwin on Sunday in one of test cricket's greatest upsets.
Djokovic falls in Cincinnati heat in first match since Wimbledon
Thiago Agustin Tirante has rallied past Novak Djokovic 2-6 6-4 6-4 at the Cincinnati Open on Saturday, as the Serbian struggled in the heat and required a medical timeout in a disappointing US Open tune-up.
Islam Makhachev wins record 17th straight fight at UFC 330
Islam Makhachev (29-1 MMA) has successfully defended his UFC welterweight championship Saturday night, defeating Ireland's Ian Machado Garry (17-2 MMA) via unanimous decision (49-46, 49-46, 48-47) while also setting an impressive record in the main event of UFC 330 in Philadelphia.
