According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
FIFA signs global partnership deal with Saudi Aramco
World football governing body FIFA has signed a partnership with oil and gas conglomerate Saudi Aramco that will run through to the end of 2027, it said in a statement on Thursday.
Everton deal Liverpool big blow with shock 2-0 derby victory
Everton's Jarrad Branthwaite and Dominic Calvert-Lewin scored in a pulsating 2-0 home victory over Liverpool in the Merseyside derby on Wednesday that could prove to be the death of the visitors' withering Premier League title hopes.
Xavi to continue as Barcelona manager, LaLiga club confirms
Barcelona boss Xavi Hernandez on Wednesday reversed his decision to step down at the end of the season and agreed to stay in charge of the LaLiga giants for the 2024-25 campaign, a club spokesperson said.
Fernandes digs Man Utd out of hole in win over Sheff Utd
Manchester United captain Bruno Fernandes came to his side's rescue with two goals in a 4-2 home victory over the Premier League's bottom club Sheffield United on Wednesday just when more trouble loomed for beleaguered manager Erik ten Hag.
Nadal uncertain over Roland Garros appearance
Spain's Rafael Nadal said on Wednesday that he is not sure if he will be able to play at next month's French Open after pushing through the pain barrier in his comeback from injury.
