According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Italy, Sweden and Denmark close in on World Cup spots
Italy moved within one win of ending their 12-year World Cup absence with a 2-0 qualification playoff semi-final victory over Northern Ireland on Thursday thanks to second-half goals from Sandro Tonali and Moise Kean.
Gauff crushes Muchova to reach Miami Open final
Coco Gauff delivered a commanding 6-1 6-1 demolition of Karolina Muchova on Thursday to book her place in the Miami Open final, her sixth WTA 1000 final.
Iran bans sports teams from travelling to countries it deems 'hostile'
Iran has banned national and club sports teams from travelling to countries it considers hostile until further notice, Iranian media reported on Thursday, citing the Sports Ministry.
Turkey edge Romania to reach World Cup playoff final
Turkey moved within one game of ending their long World Cup absence as Ferdi Kadioglu's second-half goal secured a 1-0 win over Romania in their playoff semi-final on Thursday, following a moment of brilliance from Arda Guler.
UEFA fines Benfica for fan behaviour during Real Madrid game
European soccer’s governing body UEFA said it has fined Benfica 40,000 euros ($46,250) for "racist and/or discriminatory behaviour" by supporters during their Champions League match against Real Madrid last month.
