England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Nadal uncertain over Roland Garros appearance
Spain's Rafael Nadal said on Wednesday that he is not sure if he will be able to play at next month's French Open after pushing through the pain barrier in his comeback from injury.
Arsenal hammer Chelsea to move three points clear at top
Ruthless Arsenal threw down the gauntlet in the Premier League title race with a 5-0 thrashing of London rivals Chelsea to roar three points clear at the top of the table on Tuesday.
Al-Ain seal Asian Champions League final berth despite Al-Hilal loss
Al-Ain advanced to the Asian Champions League final despite losing 2-1 to Saudi Arabia's Al-Hilal in Riyadh on Tuesday, with the side from the UAE completing a 5-4 aggregate victory to progress to next month's decider.
Inter secure Serie A title in heated win over Milan
Inter Milan won their 20th Serie A title on Monday after a 2-1 win at AC Milan gave Simone Inzaghi's side an unassailable lead in the standings.
Bellingham's strike hands Real comeback win over Barcelona
LaLiga leaders Real Madrid's pursuit of a record-extending 36th Spanish title gathered momentum after Jude Bellingham scored a goal in added time to secure a 3-2 comeback win over Barcelona on Sunday.
