England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Bangladesh claim first test win in Australia as Green ton in vain
Bangladesh has chased down 57 runs to complete a landmark nine-wicket victory over Australia in the series-opener in Darwin on Sunday in one of test cricket's greatest upsets.
Djokovic falls in Cincinnati heat in first match since Wimbledon
Thiago Agustin Tirante has rallied past Novak Djokovic 2-6 6-4 6-4 at the Cincinnati Open on Saturday, as the Serbian struggled in the heat and required a medical timeout in a disappointing US Open tune-up.
Islam Makhachev wins record 17th straight fight at UFC 330
Islam Makhachev (29-1 MMA) has successfully defended his UFC welterweight championship Saturday night, defeating Ireland's Ian Machado Garry (17-2 MMA) via unanimous decision (49-46, 49-46, 48-47) while also setting an impressive record in the main event of UFC 330 in Philadelphia.
Germany's Liebmann smashes 1500m world record
Germany's Johannes Liebmann has smashed the world record for the men's 1500 metres at the European Aquatics Championships on Saturday, knocking almost four seconds off the previous record in a dominant display.
Inter sign England defender Spence from Tottenham
Inter Milan have signed England international winger Djed Spence from Tottenham Hotspur on a contract running until June 30, 2031, the Serie A club said on Saturday.
