England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
France come from behind to thrash Belgium
France came from a goal down to beat Belgium 4-1 in their Nations League Group A1 meeting at the Stade de France on Monday, while Italy secured a 3-1 win over Turkey, their third consecutive match without a loss.
Medvedev disqualified from China Open semi after hitting ball into crowd
Russian Daniil Medvedev was disqualified from his China Open semi-final clash with Novak Djokovic after hitting a rebounding ball into the crowd, striking a spectator in the eye.
Pakistan drop Agha as T20 captain, hand Farhan role for Sri Lanka series
Pakistan have dropped Salman Ali Agha as T20 captain and left him out of the squad for this month's Sri Lanka series, while naming squads for the T20 series and ODI tri-series against Sri Lanka and England.
Alcaraz rallies past Munar into Japan Open final
Defending champion Carlos Alcaraz overcame early wobbles on his serve to outclass fellow Spaniard Jaume Munar 5-7 6-3 6-1 and reach the Japan Open final on Monday, taking a step towards his first singles title after his comeback from a wrist injury.
UAEFA provides 12 chartered flights to Gulf Cup final in Jeddah
The UAE Football Association (UAEFA) has provided 12 chartered aircraft to transport fans to Jeddah to witness the UAE national team's final match against Saudi Arabia in the Gulf Cup on Tuesday.
