England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
AC Milan, Inter complete acquisition of San Siro for new stadium project
AC Milan and Inter Milan have teamed up to complete the acquisition of the San Siro stadium and surrounding land from the city authorities, in a further step towards demolishing the venue and building a new one, the two clubs said on Wednesday.
Pant returns to India squad for test series against South Africa
Rishabh Pant will make his return to the Indian squad for the two-test series against South Africa, the country's cricket board announced on Wednesday, marking his comeback from a foot fracture that sidelined him from the series against West Indies.
Mac Allister heads Liverpool to Champions League win over Real Madrid
Liverpool's Alexis Mac Allister headed a second-half winner as the hosts earned a hard-fought 1-0 victory over Real Madrid in a battle between European giants on Tuesday, handing the LaLiga leaders their first defeat in the Champions League this season.
Sabalenka overpowers Pegula, Gauff eliminates Paolini in WTA Finals
World number one Aryna Sabalenka earned a 6-4 2-6 6-3 win over Jessica Pegula, while defending champion Coco Gauff put on a clinical performance to beat Jasmine Paolini 6-3 6-2 and eliminate the Italian in Riyadh on Tuesday.
Pakistan win ODI against South Africa in last over as Salman shows the way
Salman Ali Agha top scored for Pakistan as they snatched a last-over victory over South Africa on Tuesday in an exciting finish to the first of three One Day Internationals at Faisalabad.
