Syria's President Bashar al-Assad and his wife Asma have tested positive for COVID-19 after showing minor symptoms, his office said on Monday.
The pair are in good health and would keep working in isolation at home, the statement said.
Syria has seen a sharp rise in infections since mid-February. Health and aid officials say it remains difficult to gauge the full size of the outbreak given the lack of testing facilities in a fragile health system devastated by a decade of war.
Assad joins a growing list of world leaders who have tested positive for COVID-19, alongside Britain's Boris Johnson, France's Emmanuel Macron and former U.S. President Donald Trump.
Health workers said the authorities underplayed the size of the outbreak for most of last year, when official figures remained low as hospitals were overwhelmed and death notices appeared in newspapers.
The government denied undercounting the figures and has acknowledged in the last two months the country could be on the verge of a major spike.
It has urged people to wear face masks, take sanitary measures and avoid crowded areas.
An explosive-laden car rammed into a Pakistani military convoy on Saturday in a town near the Afghan border, killing at least 13 soldiers, sources said.
Radiation levels in the Gulf region remain normal after the 12-day Israel-Iran conflict severely damaged several nuclear facilities in Iran, Director General Rafael Mariano Grossi of the International Atomic Energy Agency (IAEA) said.
Rwanda and Democratic Republic of Congo signed a US-brokered peace agreement on Friday, raising hopes for an end to fighting that has killed thousands and displaced hundreds of thousands more this year.
The US Supreme Court on the last day of rulings for its current term gave Donald Trump his latest in a series of victories at the nation's top judicial body, one that may make it easier for him to implement contentious elements of his sweeping agenda as he tests the limits of presidential power.
Polish President Andrzej Duda arrived in Kyiv on Saturday for a meeting with Ukrainian President Volodymyr Zelenskyy, Duda's office said, as Kyiv aims to build support among allies at a critical juncture in its grinding war with Russia.