At least 12 people were killed and nine injured on Tuesday evening when gunmen opened fire at an informal settlement in Cleveland, east of Johannesburg, police said on Wednesday.
Police said in a statement that they had launched a manhunt for more than 10 suspects following the attack at the Jumpers informal settlement.
The motive for the attack is not known.
Police said the suspects arrived in a white Toyota Quantum, entered the settlement from two access points and opened fire at multiple locations before fleeing in the same vehicle.
South Africa has one of the world's highest murder rates, averaging about 60 a day.
Trump says US will attack Iran 'very hard' and has taken oil through Hormuz
GCC Ministerial Council condemns Iranian aggression
Three Indian seafarers missing after attack on tanker off Oman
Trump says Iran must 'pay the price' for delay on deal
Homes set alight in Belfast anti-immigrant protests after 'brutal' knife attack
