Top seed Karolina Pliskova has crashed out of the US Open following a straight-sets defeat in the second round.
The world no.3 lost 6-1, 7-6 (2) to France’s Caroline Garcia, who will now face 28th seed, American Jennifer Brady.
Elsewhere, sixth seed Petra Kvitova overcame a shaky start to defeat Kateryna Kozlova 7-6 (3), 6-2 in her second-round match, while the 2018 champion, Naomi Osaka, cruised past Camila Giorgi 6-1, 6-2.
In the men’s draw, top seed Novak Djokovic overcame Kyle Edmund 6-7 (7-5), 6-3, 6-4, 6-2 to set up a third-round matchup against No. 28 Jan-Lennard Struff.
Fourth seed Stefanos Tsitsipas also advanced to the third round following a 7-6 (2), 6-3, 6-4 win over wild card Maxime Cressy.
David Beckham knighted for services to sport and charity
Aryna Sabalenka challenges Nick Kyrgios in Dubai showdown
Dubai Basketball continues unbeaten home run with win over Partizan
Sunderland's Xhaka earns draw after Ndiaye's stunner for Everton
Rybakina enters semis, Anisimova beats Keys in WTA Finals
