Cristiano Ronaldo grabbed two goals in his country's 6-0 thrashing of Luxembourg in a Euro 2024 qualifier on Sunday, giving them a second win in four days.
The 38-year-old grabbed a double against Liechtenstein on Thursday and scored twice more in Luxembourg to extend his record tally of international goals to 122 in 198 appearances.
Joao Felix, Bernardo Silva, Otavio and Rafael Leao added the other goals to put Portugal top of Group J after an easy start to their qualifying campaign.
Elsewhere, Harry Kane underlined his status as England's greatest international goalscorer and Bukayo Saka dazzled again in a comfortable 2-0 win over Ukraine to put Gareth Southgate's team in control of Group C.
Fresh from scoring his 54th goal in the 2-1 victory over Italy on Thursday, Kane made up for a couple of missed chances to break the stalemate in the 37th minute.
Arsenal youngster Saka, again England's brightest spark, then doubled the lead before halftime with a sensational curler that left the visitors and their 4,000 fans deflated.
Ukraine had their moments and enjoyed some pressure after the interval but never really looked capable of claiming only a second victory over England in 10 attempts.
Meanwhile, goals by forward Mateo Retegui and midfielder Matteo Pessina steered Italy to a 2-0 win over Malta in the other Group C clash.
Italy opened the scoring in the 15th minute when Retegui broke free from his marker to power in a header from a corner with Pessina doubling the lead after 27 minutes when he tapped Emerson's cross in from a short distance.
Vincenzo Grifo was close to make it three for the visitors shortly after but Malta goalkeeper Henry Bonello skilfully blocked his attempt.
Italy came close to increasing their lead in the second half when Gianluca Scamacca produced an overhead kick from a corner but Bonello came to the rescue again with a one-handed reaction save.
Other matches in the second round saw Slovakia beat Bosnia and Herzegovina 2-0, Iceland crush Liechtenstein 7-0, Kazakhstan overcome Denmark 3-2, Slovenia beat San Marino 2-0, and Finland edge Northern Ireland 1-0.