According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Fils claims first ATP Masters title, Gauff clinches second Cincinnati crown
Arthur Fils has defeated Frances Tiafoe to secure his first ATP Masters 1000 title on Sunday, while Coco Gauff beat Jessica Pegula to win her second Cincinnati Open title.
Barcelona launch LaLiga title defence with five-star Elche demolition
Barcelona has begun their LaLiga title defence and bid for a third successive crown with a 5-0 victory at Elche on Sunday as Raphinha and Fermin Lopez scored twice each.
Torres double rescues point for PSG at Rennes in Ligue 1 opener
Ferran Torres has come off the bench to score a late double on his debut as Paris St Germain rallied from two goals down to draw 2-2 with hosts Stade Rennais in their Ligue 1 season opener on Sunday.
F1 confirms Abu Dhabi Grand Prix will close 2026 season
Formula One will end the 2026 season in Abu Dhabi's Yas Marina Circuit, reaffirming the championship’s commitment to the scheduled calendar.
Norris wins Dutch GP as Antonelli stretches his F1 lead
Lando Norris has given McLaren a third successive Dutch Grand Prix victory on Sunday in an intense race of shifting fortunes that had to be restarted after home hero Max Verstappen crashed on the opening lap.
