According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
First-half goals send Mexico to comfortable 2-0 victory over Ecuador
Julian Quinones delivered a goal and an assist in the first half for Mexico, who maintained complete control in front of their vocal home fans to earn a 2-0 World Cup victory over Ecuador in a round of 32 match on Tuesday at Mexico City.
Mbappe scores twice as France ease past Sweden 3-0 to reach last 16
Kylian Mbappe scored twice as France swept aside Sweden 3-0 in the World Cup round of 32 on Tuesday, maintaining their perfect record of four wins from four and setting up a last-16 meeting with Paraguay.
Serena and Wawrinka go down fighting at Wimbledon
Serena Williams returned to competitive singles action on Tuesday amid huge fanfare after a four-year absence but the American icon could not overcome the first hurdle at Wimbledon and was beaten 6-3 6-7(6) 6-3 by Australian Maya Joint.
Norway edge Ivory Coast to advance at World Cup
Erling Haaland shattered Ivory Coast's World Cup hopes on Tuesday, netting an 86th-minute winner that sent Norway into the last 16 with a 2-1 victory at Dallas Stadium.
Australia knock West Indies out to reach Women's T20 World Cup final
Australia moved a step closer to a record-extending seventh Women's T20 World Cup title after beating West Indies by eight wickets in the first semi-final at The Oval on Tuesday.
