According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Sabalenka to skip events in 2026 to prioritise health
Aryna Sabalenka expects to skip events again this year rather than put her health at risk over the course of an "insane" season, even though she knows she is likely to be sanctioned by the WTA Tour for doing so, the world number one said.
Australia achieve series triumph in final Ashes Test
Australia had a few nervous moments but safely chased down their 160-run victory target before tea on the final day of the fifth Ashes Test on Thursday for a five-wicket victory and a 4-1 series triumph.
Sebastian Vettel heads to Sharjah for Entrepreneurship fest
Four-time Formula One World Champion Sebastian Vettel is among a host of illustrious speakers headed to the ninth edition of the Sharjah Entrepreneurship Festival.
Arsenal get title boost as Man City and Villa both drop points
Arsenal's Premier League title prospects have been enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
Bethell's maiden century stalls Australia's victory march in fifth Ashes test
Jacob Bethell scored his maiden test century to lead an England rearguard action on the fourth day of the fifth test on Wednesday but Australia still looked firmly set for victory and a 4-1 series triumph.
