According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Augsburg score fastest Bundesliga goal but Bayern snatch comeback draw
Augsburg's Robin Fellhauer scored after eight seconds of the game against visitors Bayern Munich on Saturday to record the fastest goal in Bundesliga history, but the German champions twice came from a goal down to snatch a 2-2 draw.
Red Bull's Verstappen fastest in Singapore to claim 50th career pole
Red Bull's Max Verstappen has claimed the 50th pole position of his career when he went fastest in qualifying under the lights at the Singapore Grand Prix on Saturday, repeating his heroics from the sprint qualifying session a day earlier.
Ronaldo provisionally suspended after national team walkout, media reports say
Cristiano Ronaldo has been provisionally suspended by the Portuguese Football Federation (FPF) after disciplinary proceedings were opened over the striker's departure from the national team camp, Portuguese media reported on Saturday.
Guimaraes grabs winner as Arsenal rally to beat Leeds
Arsenal has come back from a goal down to beat Leeds United 2-1 at the Emirates Stadium on Saturday, with Brazilian Bruno Guimaraes coming off the bench to net the winner as the Premier League resumed following a lengthy international break.
Verstappen wins Singapore sprint after chaotic start in wet conditions
Red Bull's Max Verstappen tasted victory in Singapore for the first time as the polesitter won a chaotic sprint on Saturday after the start was delayed by over 30 minutes due to heavy rain while nine cars retired, a record for sprint races.
