According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
Alcaraz pulls out of Madrid Open for second straight year
Carlos Alcaraz will miss the Madrid Open for the second consecutive year after withdrawing on Friday with a wrist injury, dealing another blow to the world number two's clay court preparations ahead of his French Open title defence.
Injured Djokovic to miss Madrid Open
Novak Djokovic is still working through the injury problems that forced him to miss recent tournaments in Miami and Monte Carlo and said on Friday that he will not feature at next week's Madrid Open, one of the last stops before the French Open.
Mumbai's IPL campaign fizzles amid Bumrah's barren run
Mumbai Indians head coach Mahela Jayawardene has defended Jasprit Bumrah after the struggling pace spearhead went a fifth Indian Premier League match without a wicket in Thursday's seven-wicket defeat by Punjab Kings.
Iran women football players thank Australian government for protection
Iranian women's football players Fatemeh Pasandideh and Atefeh Ramezanisadeh thanked the Australian government on Friday for offering a "safe haven" and said they wished to resume their sporting careers after rebuilding their lives.
Villa's Watkins looking to make late push for England World Cup squad
Ollie Watkins still has hope of making England's World Cup squad despite being dropped for last month's friendlies against Uruguay and Japan, with the Aston Villa forward saying all he can do in the last few weeks of the season is score goals.
