According to manager Ole Gunnar Solskjaer, the France midfielder needs an operation on his ankle.
The 26-year-old only made his comeback last month, as his ankle problem kept him out since late September last year.
Scott McTominay is currently also out injured.
Pogba has played only eight times this season after having surgery to correct another ankle injury.
UAE-Iraq World Cup qualifier playoff ends in draw
The UAE and Iraq played out a 1-1 draw in the first leg of their 2026 FIFA World Cup qualifier playoff in Abu Dhabi.
Mbappe helps France secure World Cup spot on Paris attacks anniversary
France's expertise in qualifying was in full display again as they have booked a spot for their eighth consecutive World Cup after a Kylian Mbappe double helped to secure a 4-0 home victory against Ukraine on Thursday.
Alcaraz clinches year-end top spot with ATP Finals win over Musetti
Carlos Alcaraz clinched the year-end world number one ranking and secured top spot in the Jimmy Connors Group with a 6-4 6-1 win over Lorenzo Musetti at the ATP Finals on Thursday, a result that also sent Alex De Minaur into the semi-finals following his victory over Taylor Fritz.
Dubai unveils ambitious plan to become world's top sporting city
Dubai has unveiled an ambitious Sports Sector Strategic Plan 2033, setting a bold goal for the emirate to become the world’s top sporting city within the next decade.
Michael Kim opens up one-shot lead in Dubai
Michael Kim produced a brilliant burst of scoring on the back nine to lead by one shot after the first round of the 2025 DP World Tour Championship.
