India posted 571 in reply to Australia's first-innings total of 480 to claim a 91-run lead in the fourth and final Test on Sunday.
Virat Kohli top-scored for the home side with a mammoth 186 while opener Shubman Gill (128) also smashed a hundred.
Spinners Nathan Lyon and Todd Murphy claimed three wickets apiece for Australia.
For India, who lead the series 2-1, Shreyas Iyer could not bat because of back pain.
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Michael Kim opens up one-shot lead in Dubai
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New Zealand down West Indies in Dunedin to seal T20 series win
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Pakistan to host T20 tri-series in Rawalpindi after bombing
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