England beat Ireland and France by 12 and 36 points respectively in their first two matches of the campaign.
They are currently ranked third in the world.
Play from the Millennium Stadium in Cardiff gets underway at 8:45 PM UAE time.
Meanwhile Scotland travel to France for their latest Six Nations fixture.
Action from the Stade de France starts at 6:15 PM UAE time.
Semenyo magic hands Man City 1-0 FA Cup win over Chelsea
Manchester City's Antoine Semenyo produced a moment of magic to win the FA Cup on Saturday, a 1-0 victory over Chelsea completing an English cup double for Pep Guardiola's side.
Svitolina fights off Gauff to win third Italian Open title
Elina Svitolina signalled her French Open ambitions by battling past world number four Coco Gauff 6-4 6-7(3) 6-2 in the Italian Open final on Saturday to lift her first claycourt title of the season ahead of Roland Garros.
Chelsea agree deal with Alonso to take over as head coach, reports say
Chelsea have agreed a four-year deal with former Real Madrid and Bayer Leverkusen manager Xabi Alonso to become the Premier League club's head coach, Sky Sports reported on Saturday.
Kane grabs hat-trick as champions Bayern crush Cologne
Bundesliga top scorer Harry Kane scored a hat-trick to guide champions Bayern Munich to a 5-1 demolition of visitors Cologne in the league finale on Saturday.
Sinner beats Medvedev to set up Italian Open final with Ruud
World number one Jannik Sinner had a restless night before completing a rain-interrupted victory over Daniil Medvedev to reach the Italian Open final on home soil on Saturday.
