Roger Federer has crashed out of the Cincinnati Masters.
The seven time winner suffered a shock straights sets defeat to 21-year-old Russian qualifier Andrey Rublev.
The third round win means Rublev will now face compatriot Daniil Medvedev in the quarter-finals.
Meanwhile world number one Novak Djokovic is through to the final eight after an easy win over Pablo Carreño Busta.
Ten-man Newcastle beat Man United; Arsenal go 7 points clear
William Osula came off the bench to score a late winner as a 10-man Newcastle United beat high-flying Manchester United 2-1 in the Premier League on Wednesday to end Michael Carrick's unbeaten run as interim manager.
New Zealand crush South Africa to reach T20 World Cup final
Finn Allen plundered the fastest century in Twenty20 World Cup history to lead New Zealand into the final with a nine-wicket demolition of South Africa at the Eden Gardens on Wednesday.
Dave Rennie becomes first Pacific Islander to lead All Blacks
Dave Rennie was named as replacement for Scott Robertson as coach of the All Blacks on Wednesday and charged with taking New Zealand to a fourth World Cup triumph in Australia next year.
FIFA offering $12 tickets to World Cup Play-Off Tournament
Tickets for this month's World Cup Play-Off Tournament matches in Mexico, which will determine two of the final six vacant spots in this summer's historic 48-team tournament, went on sale Tuesday.
Resurgent Wolves stun Liverpool, Everton enjoy home comfort
Resurgent bottom club Wolverhampton Wanderers have stunned Liverpool with a last-gasp 2-1 win at a rocking Molineux on Tuesday to offer a glimpse of a miraculous escape from relegation while putting a big dent in the top-five hopes of Arne Slot's side.
