England bowled West Indies out for 45 - the second lowest total in international Twenty20 history - to win by 137 runs in St Kitts.
Joe Root's 55 runs and Sam Billings' brilliant knock of 87 off 47 balls helped to win with ease, taking an unassailable 2-0 lead in the series.
This is England's biggest margin of victory by runs in T20s and the fourth biggest of all time.
The final T20 will be played in St Kitts at 20:00 GMT on Sunday.
Norway edge Ivory Coast to advance at World Cup
Erling Haaland shattered Ivory Coast's World Cup hopes on Tuesday, netting an 86th-minute winner that sent Norway into the last 16 with a 2-1 victory at Dallas Stadium.
Australia knock West Indies out to reach Women's T20 World Cup final
Australia moved a step closer to a record-extending seventh Women's T20 World Cup title after beating West Indies by eight wickets in the first semi-final at The Oval on Tuesday.
Swiatek struggles to Wimbledon first-round victory, Svitolina crashes out
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Anisimova and Paolini make winning return to Wimbledon
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Zimbabwe win test against Bangladesh in three days
Zimbabwe won their one-off home test against Bangladesh in three days as they skittled the tourists out on Tuesday to win by an innings and 85 runs for their biggest test victory.
