Ailing Sinner knocked out in French Open second round by Cerundolo

Jannik Sinner's bid for a maiden French Open title and career Grand Slam went up in smoke as he experienced physical issues in his second-round match against Juan Manuel Cerundolo and fell to a 3-6 2-6 7-5 6-1 6-1 defeat on a scorching Thursday.

Sinner arrived in Paris as the favourite for the title having lifted claycourt titles in Monte Carlo, Madrid and Rome, with his main rival and defending champion Carlos Alcaraz ruled out with injury and Novak Djokovic searching for his best form.

But Cerundolo tore up the script in a dramatic clash where he held his nerve even as last year's runner-up Sinner crumbled while on the verge of a big win, sending shockwaves through Roland Garros.

"It's tough for him. He was winning the match. I couldn't win more than three games (in any of the first two sets)," said Cerundolo. "I think I was a little bit lucky, I feel sorry for him ... he was serving to win this match, but then I don't know what happened. I think he was cramping maybe, or maybe it was the pressure of the match, I don't know.

"But of course I feel sorry for him and I hope he recovers. I'm super happy. I'm going to keep trying to play my best... I hope to be ready for the next match."

As the temperature climbed over the 30 degrees Celsius mark for the first time in the afternoon, Sinner had already breezed through the first set on the back of a solitary break, and the 24-year-old Italian looked to be in cruise mode.

Cerundolo offered resistance towards the end of the second set, but the 56th-ranked Argentine was left with a mountain to climb after Sinner unleashed a huge forehand winner to double his lead in the match for the loss of only five games.

The four-times Grand Slam champion cooled off with an ice towel in the break and turned up the intensity on his unseeded opponent in the third set to go 5-1 ahead, before he began to struggle and halted play when serving at 5-4.

"In the third set I felt dizzy and I wanted to vomit but I couldn't," the Italian was heard saying to an official, before he stepped off the court for a medical timeout.

Sinner returned five minutes later and was immediately broken for 5-5, and dropped the next two games to hand the set to his Argentine opponent, who sensed the chance to pull off a major upset.

Hitting heavier to quicken the points and also serving and volleying frequently, Sinner looked desperate to avoid the exit but his troubles only increased as he began to clutch his right thigh in the fourth set, which he surrendered tamely.

Quickly losing control, Sinner was broken early in the decider, as Cerundolo took full advantage to leave the Paris Grand Slam without its title favourite and Djokovic with a golden opportunity to win a standalone 25th major.