The US-born giant panda Bei Bei has left his home at Washington's National Zoo for China.
Bei Bei will travel on a specially equipped flight from Washington to Chengdu, accompanied by his keeper and a veterinarian.
The giant panda turned four years - the age when all pandas born outside return to China under their breeding agreements.
"Today is bittersweet. We've cared for Bei Bei, and along with millions, watched him grow into a true ambassador for his species," said zoo director Steve Monfort.
"We look forward to continuing our 47-year giant panda conservation program and collaboration with Chinese colleagues to study, care for and help save the giant panda and its native habitat."
Zoo officials said they had prepared a special stash of treats for him: 30 kilos of bamboo, two pounds of apples and pears, two pounds of cooked sweet potatoes, two bags of biscuits and water.
Prince Harry said on Friday that he wanted reconciliation with the British royal family but his father King Charles will not speak to him over a row over his security and he did not know how long the monarch, who has cancer, would live.
A magnitude 7.4 earthquake struck Drake Passage between Cape Horn and Antarctica at a depth of 10 km (6 miles) on Friday, the United States Geological Survey said.
A ship with humanitarian aid and activists for Gaza was bombed by drones while in international waters off Malta early on Friday, its organisers said, and the Maltese government said after a rescue operation that everyone on board was safe.
A power outage hit several regions of Indonesia's resort island of Bali on Friday and efforts were underway to restore services to those affected, state utility Perusahaan Listrik Negara said.
A Russian drone attack late on Thursday set buildings ablaze in Ukraine's southeastern city of Zaporizhzhia, injuring 29 people, regional governor Ivan Fedorov said.