The US-born giant panda Bei Bei has left his home at Washington's National Zoo for China.
Bei Bei will travel on a specially equipped flight from Washington to Chengdu, accompanied by his keeper and a veterinarian.
The giant panda turned four years - the age when all pandas born outside return to China under their breeding agreements.
"Today is bittersweet. We've cared for Bei Bei, and along with millions, watched him grow into a true ambassador for his species," said zoo director Steve Monfort.
"We look forward to continuing our 47-year giant panda conservation program and collaboration with Chinese colleagues to study, care for and help save the giant panda and its native habitat."
Zoo officials said they had prepared a special stash of treats for him: 30 kilos of bamboo, two pounds of apples and pears, two pounds of cooked sweet potatoes, two bags of biscuits and water.
Cuban forces have killed four exiles and wounded six others who sailed into Cuban waters aboard a Florida-registered speedboat on Wednesday and opened fire on a Cuban patrol, the Cuban government said at a time of heightened tensions with the United States.
The death toll from the heavy rains in Brazil's southeastern state of Minas Gerais has risen to 46, according to figures released by the state fire department on Wednesday.
A nearly blind refugee from Myanmar missing since his release from a Buffalo jail into the custody of US Border Patrol has been found dead on a downtown street, city authorities said on Wednesday.
A record 129 journalists and media workers were killed in the course of their work last year, two-thirds of them killed by Israel, the Committee to Protect Journalists said on Wednesday.
Britain on Wednesday rowed back from saying it had paused ratification of a deal to cede sovereignty of the Chagos Archipelago, which is home to a strategically important US-UK air base.