Around one million people have fled the Gazan city of Rafah in the past three weeks, the United Nations Palestinian refugee agency (UNRWA) said on Tuesday.
The small city on the southern edge of the Gaza Strip had been sheltering more than a million Palestinians who fled Israeli assaults on other parts of the enclave.
Since early May, Israel's military has been carrying out what it says is a limited operation in Rafah to kill fighters and dismantle infrastructure used by Hamas. It has told civilians to go to an "expanded humanitarian zone" some 20 kilometres away.
Many Palestinians have complained they are vulnerable to Israeli attacks wherever they go and have been moving up and down the Gaza Strip in the past few months.
UNRWA said the flight from Rafah "happened with nowhere safe to go and amidst bombardments, lack of food and water, piles of waste and unsuitable living conditions."
Providing assistance and protection is becoming nearly "impossible", the agency said.
Israel intensified strikes on Gaza hours after a ceasefire and hostage release deal was announced, residents and authorities in the Palestinian enclave said, and mediators sought to quell fighting ahead of the truce's start on Sunday.
Prime Minister and Minister of Foreign Affairs Sheikh Mohammed bin Abdulrahman bin Jassim Al-Thani announced that the joint mediation efforts of Qatar, Egypt and the United States secured a Gaza ceasefire and prisoner swap deal between Hamas and Israel.
Negotiators reached a deal on Wednesday for a ceasefire in the Gaza war between Israel and Hamas, an official briefed on the negotiations said, after 15 months of conflict that has killed tens of thousands of Palestinians.
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