NASA's next-generation Mars rover Perseverance blasted off from Florida's Cape Canaveral on Thursday atop an Atlas 5 rocket on a $2.4 billion mission to search for traces of potential past life.
Perseverance is due to land at the base of an 820-foot-deep crater called Jezero, a former lake from 3.5 billion years ago that scientists suspect could bear evidence of potential past microbial life on Mars.
It is expected to reach Mars next February.
Scientists have long debated whether Mars - once a much more hospitable place than it is today - ever harbored life. Water is considered a key ingredient for life, and the Mars billions of years ago had lots of it on the surface before the planet became a harsh and desolate outpost.
The next-generation robotic rover - a car-sized six-wheeled scientific vehicle - is also scheduled to deploy a mini helicopter on Mars and test out equipment for future human missions to the fourth planet from the sun.
This marked NASA's ninth journey to the Martian surface.
This was scheduled as the third launch from Earth to Mars during a busy month of July, following probes sent by the United Arab Emirates and China.
The US and Iran failed to reach an agreement to end their war despite marathon talks that concluded on Sunday in the Pakistani capital Islamabad, jeopardising a fragile ceasefire.
Russia and Ukraine accused each other on Sunday of breaching the 32-hour ceasefire in their four-year war, reporting more than a thousand drone and shelling attacks just hours after the truce began on Saturday to mark Orthodox Easter.
At least 30 people were killed on Saturday in a stampede at the Laferriere Citadel in the northern countryside of Haiti, authorities said, warning that the death toll could rise.
A cyclone battered New Zealand's North Island on Sunday, cutting power to thousands of residents and forcing hundreds to evacuate, as officials warned conditions would worsen through the day.
Negotiations between the United States and Iran appeared to have concluded for now, Iran's government has announced early on Sunday, after a series of talks in Pakistan to end the six-week war between Washington and Tehran.