Bahrain will suspend dine-in services at restaurants and cafes and move public and private schools to remote learning for three weeks to contain the spread of the coronavirus, the health ministry said.
It said it had detected a new variant of coronavirus in a number of cases, without specifying which kind.
The new lockdown measures will come into effect on Sunday.
There has been an uptick in coronavirus cases in the Gulf kingdom since December. The country registered 459 new cases on Wednesday, adding to a total of nearly 100,000 since the start of the pandemic, with 370 deaths.
The small island state has the third highest rate of vaccinations per capita in the world so far, according to the Our World in Data website, which is run by an Oxford University research programme.
Bahrain offers its citizens either the Pfizer/BioNTech vaccine or one manufactured by Chinese state-backed pharmaceutical giant Sinopharm free of charge.
The kingdom also approved the AstraZeneca COVID-19 vaccine on Monday for emergency use.
Some departing flights at major British airports were disrupted on Tuesday after air traffic control provider NATS experienced a technical issue, with Heathrow, Gatwick, Manchester and Stansted among the airports affected by restrictions and delays.
At least 73 civilians have been injured after Yemen's Houthi rebels attacked a number of civilian and energy facilities in Saudi Arabia's southern region on Tuesday, state media confirmed.
Britain, France and Canada on Tuesday moved to block imports from Israeli settlements in the occupied West Bank, as a wider group of countries signalled further steps to defend the two-state solution amid mounting concern over settlement expansion.
German police have detained a 48-year-old man suspected of carrying out a series of sabotage attacks on the country's electricity grid, police and prosecutors said on Tuesday.
Rescuers in Nepal are focusing on three hydropower project tunnels where they believe dozens of workers could be trapped, authorities said on Tuesday, two weeks after a devastating flood killed hundreds and left thousands missing.