At least seven people were killed and thirty injured on Saturday in a car blast in a busy market place in the rebel held Syrian town of Azaz near the Turkish border.
Residents and rescuers said the blast occurred during peak late night shopping after the breaking of the fast during the holy month of Ramadan.
"It's timing comes with heavy congestion by shoppers," said Yaseen Shalabi who was near the site of the explosion shopping with his family.
There was no immediate claim of responsibility.
The Arab-populated town run by Syrian rebel groups backed by Turkey opposed to Syrian President Bashar al Assad has been relatively quiet since it was hit by a car blast over two years ago.
Main towns in the north-western border area have in recent years been frequently hit by bombings detonated in crowded civilian areas.
Residents and rebels in the mainly Arab-populated rebel-held northwest have long suspected the Kurdish led YPG who control large swathes of areas in northeast Syria and east of the Euphrates in northern Syria. Others blame groups loyal to Assad.
US President Donald Trump said on Wednesday that a US-backed ceasefire in Gaza was not at risk after Israel launched airstrikes in the enclave, which killed 26 people in response to the killing of an Israeli soldier.
One person was killed on India's eastern coast after Cyclone Montha made landfall around midnight, with heavy rain and gusty winds also damaging crops and utility poles, officials said on Wednesday.
Floods triggered by record heavy rains have killed at least nine people and left five others missing in central Vietnam, the government said on Wednesday.
Hurricane Melissa churned toward Cuba's second-largest city with the force of a powerful Category 4 storm on Tuesday, hours after making landfall in neighbouring Jamaica as the strongest-ever cyclone on record to hit that Caribbean island nation.
The Arab League has warned against the escalation of wars in the region and the continued practices of the Israeli occupation in the Arab territories in posing a real threat to the region's development and human resources.