Todd Phillips' 'Joker' won the Golden Lion award at the Venice Film Festival.
Joker, starring Joaquin Phoenix, had received an eight-minute standing ovation at its premiere in the Italian city on Saturday.
"I want to thank Warner Bros and DC for stepping out of their comfort zone and taking such a bold swing on me and this movie," director Todd Phillips said in his acceptance speech.
"There is no movie without Joaquin Phoenix ... Joaquin is the fiercest and bravest and most open-minded lion that I know."
The movie follows superhero Batman's nemesis' transformation from vulnerable loner to confident villain.
Meanwhile, Roman Polanski's military drama An Officer and a Spy took the Silver Lion Grand Jury Prize.
Italian actor Luca Marinelli won best actor for Martin Eden, while France's Ariane Ascaride won best actress for Gloria Mundi.
Best director went to Sweden's Roy Andersson About Endlessness, while Italian director Franco Maresca won the Special Jury Prize for satirical documentary Mafia Is No Longer What It Used to Be.
Best screenplay went to Chinese filmmaker Yonfan for the animation No. 7 Cherry Lane.
A tech billionaire's secret survival bunker inspired Florian Zeller's latest film, which premiered at the Venice Film Festival on Tuesday, providing a warning about isolation, power and a world controlled by a wealthy few.
Family members of a 14-year-old girl whom the recording artist known as D4vd is charged with fatally stabbing and dismembering have filed a wrongful death lawsuit against the singer and some of his associates, news media outlets reported on Tuesday.
The White House has released a new arcade website where users play 1980s-style video games that block "the coming horde" at the US-Mexico border, fill Trump Accounts for children and pursue other priorities of President Donald Trump.
The UAE National Orchestra opens its second season with "To This Land, We Belong", an ode to the nation, featuring three opening concerts by celebrated Emirati composers Khalid Nassir, Ali Kano, and Fayez Al Saeed.